The Cromemco System Two Z-2D featured a modular design, with a separate processor board and terminal/display board. It utilized the Z80 processor running at a clock speed of 4 MHz, which was quite fast for its time. The system had 64 KB of RAM and supported up to 1 MB of memory using expansion boards. It also had two double-density 8-inch floppy disk drives as its primary storage medium, with each drive capable of storing 1 MB of data.

The Z-2D was primarily used in business and scientific applications, as well as by hobbyists and early computer enthusiasts. It ran the Cromix operating system, which was a multi-user, multitasking Unix-like operating system developed by Cromemco.

In terms of peripherals, the Cromemco System Two Z-2D could be expanded with various options, including additional disk drives, printers, and graphics display systems. It also had a range of programming languages and software available, including FORTRAN, BASIC, and Pascal.

The System Two Z-2D was a popular and well-regarded system in its time, known for its robustness and expandability. However, it eventually became obsolete as more advanced computer systems were introduced in the following years.